ChloroquineV1, Main, Exploration, bibRecord, 001093

The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition

Identifieur interne : 001093 ( Main/Exploration ); précédent : 001092; suivant : 001094

The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition

Auteurs : Faustine Dubar [France] ; Christian Slomianny [France] ; Jamal Khalife [France] ; Daniel Dive [France] ; Hadidjatou Kalamou [France] ; Yann Guerardel [France] ; Philippe Grellier [France] ; Christophe Biot [France]

Source :

Angewandte Chemie International Edition [ 1433-7851 ] ; 2013-07-22.

RBID : Hal:mnhn-02070060

English descriptors

mix :
- bioorganometallic chemistry, ferroquine, malaria, reactive species, subcellular imaging.

Abstract

Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.

Url:

https://hal-mnhn.archives-ouvertes.fr/mnhn-02070060

DOI: 10.1002/anie.201303690

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000232
to stream Hal, to step Curation: 000232
to stream Hal, to step Checkpoint: 000131
to stream Main, to step Merge: 001094
to stream Main, to step Curation: 001093

Le document en format XML

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<country>France</country>
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</author>
<author><name sortKey="Guerardel, Yann" sort="Guerardel, Yann" uniqKey="Guerardel Y" first="Yann" last="Guerardel">Yann Guerardel</name>
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          <idno type="ISNI">0000 0004 0638 7509</idno>
          <idno type="RNSR">199812904P</idno>
          <orgName>Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576</orgName>
          <orgName type="acronym">UGSF</orgName>
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          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
              <country key="FR"></country>
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          <orgName>Université de Lille</orgName>
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          <desc>            <address>              <addrLine>Lille</addrLine>
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          <date type="start">1946-05-18</date>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
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<tutelle name="UMR 7245" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
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          <orgName type="acronym">UGSF</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Université de Lille Sciences et technologies - UMR8576 CNRS Cité Scientifique - Bâtiment C9 F-59655 Villeneuve d’Ascq Cedex</addrLine>
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          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
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</tutelle>
<tutelle name="UMR8576" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1409" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
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</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1002/anie.201303690</idno>
<series><title level="j">Angewandte Chemie International Edition</title>
<idno type="ISSN">1433-7851</idno>
<imprint><date type="datePub">2013-07-22</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>bioorganometallic chemistry</term>
<term>ferroquine</term>
<term>malaria</term>
<term>reactive species</term>
<term>subcellular imaging</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Metal health: Ferroquine is a ferrocene-based analogue of the antimalarial drug chloroquine. In addition to the primary mechanism of quinoline action, fluorescent probe studies in infected red blood cells show another mechanism is at work. It is based on the production of HO(·) in the acidic and oxidizing environment of the digestive vacuole of the malaria parasite and implies that, with ferroquine, reinvasion can be inhibited.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Dubar, Faustine" sort="Dubar, Faustine" uniqKey="Dubar F" first="Faustine" last="Dubar">Faustine Dubar</name>
</noRegion>
<name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
<name sortKey="Guerardel, Yann" sort="Guerardel, Yann" uniqKey="Guerardel Y" first="Yann" last="Guerardel">Yann Guerardel</name>
<name sortKey="Kalamou, Hadidjatou" sort="Kalamou, Hadidjatou" uniqKey="Kalamou H" first="Hadidjatou" last="Kalamou">Hadidjatou Kalamou</name>
<name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
<name sortKey="Slomianny, Christian" sort="Slomianny, Christian" uniqKey="Slomianny C" first="Christian" last="Slomianny">Christian Slomianny</name>
</country>
</tree>
</affiliations>
</record>

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The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition

The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition

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